Top Definition
Graphical User Interface.

A visual display of files, programs, and program directories designed to make it easier for a person to use a computer.
Microsoft Windows has an easy-to use GUI.
بواسطة AYB ابريل 4, 2003
Photos & Videos
the way a dyslexic person would spell "guys"
person one: lol u guis crack me up!

jenny and sue: lmao! did he just say guis!?!?
بواسطة meadowlark3000 مايو 11, 2009
Get Up In , when seeing one of your friends creepin on a person you yell it as a code word as to not let the person whos getting creeped on know that you just told you friend to have sex with that person
at the bar or at school "dam josh is really creepin on that chick, G.U.I. bro!! "
بواسطة suga ehans ابريل 3, 2011
The noise you make when something enters your asshole
Bill: GUI, GUI, GUI, yea, shove that loaf of bread in my asshole more Steve
Steve: Ok Bill. Your turn.
Bill: alrighty:
Steve: GUI GUI GU- OUCH! That really hurt bill
بواسطة GUIMACHINE123 سبتمبر 16, 2013
The act of drinking a large amount of alcohol, and gobbling like a turkey.
Jim drank a whole bottle of Dack Janiels and gobbled loudly and waddled around like a turkey for well over ten minutes. Then soon after, a police officer tasered him, cuffed him, and took him into custody. He's going to do six months community service for his G.U.I. That poor bastard.
بواسطة CHEEZITJEzUS يوليو 19, 2013
dutch for cool, awesome

(tof, gaaf, biekwauzend)
In dutch you would say:
'Die website is guis !'

means: 'That website is awesome'
بواسطة Kozie يوليو 10, 2008
pronounced as Jooey: Sometimes you just cant decide wether you'd rather play some good old fashioned COD or get a nice blow from your girlfriend. Why not settle for both. This is where the GUI come in... Gaming under the influence. Now you can play with both sticks at the same time.

This the ultimate gaming experience. So get your girl, get your XBox and get under the influence.
Tommy was ignoring his girlfriend Laura, being he was in the middle of level 27 on Nazi Zombies. In order to resolve this conflict Laura proposed a GUI, which allowed him to keep his tip wet and destroy some zombies all at the same time.
بواسطة Lulu&AmDam اكتوبر 25, 2010

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